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It's a lofty position that is well deserved, and it's likely to endure even as scientists develop new and better medications, including a new generation of "super-statins." Repatha ® is an injectable prescription medicine used:. in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery. Alirocumab reduced risk of MACE vs placebo (9.5% vs 11.1%; hazard ratio [HR]=0.85, 95% CI, 0.78-0.93), with comparable reductions in both risk categories. Repatha cut LDL-C levels from baseline by 56.9% compared with placebo in HIV patients with abnormally high cholesterol and at elevated risk of … Praluent and Repatha are for adults with heterozygous familial hypercholesterolemia (HeFH), an inherited condition that causes high levels of LDL cholesterol in … Lowering Cholesterol with Repatha: Back in 2015, the FDA approved evolocumab (Repatha) based on the drug’s ability to lower so-called bad LDL cholesterol dramatically. The prescription alternatives for those who cannot tolerate a statin include Zetia (ezetimibe) — which works by preventing cholesterol absorption from the intestine — and the injectable, expensive PCSK-9 inhibitors (Repatha and Praluent). In the summer of 2015, the FDA approved both Praluent and Repatha to lower cholesterol. However, the U.S. Food & Drug Administration no longer recommends routine monitoring for statin users. Most cholesterol medications lower cholesterol with few side effects, but effectiveness varies from person to person. Taking Zetia alone does not lower your cholesterol that much, only 15% to 20%. These injectable medications belong to a brand new class of medications and are being prescribed to people like Matt who cannot tolerate statins. They are antibodies (hence the suffix “mab”) that inhibit an enzyme (PCSK9) that controls levels of LDL cholesterol. The injectable drugs work but and are prohibitively expensive for many. 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